王丽课题组

王丽课题组

　　Li Wang Lab

　　课题组长

　　王丽，所聘研究员。2006年武汉大学本科毕业，2011年获得中国科学院植物研究所植物进化方向博士学位，其后相继在美国德州理工大学，爱荷华州立大学和加州大学戴维斯分校从事博士后研究。以第一作者或并列第一作者发表共8篇SCI收录论文，分别发表于Genome Biology, New Phytologist等国际期刊。

 

　　工作经历

　　2019.7—现在           中国农业科学院农业基因组研究所        研究员  

　　2018.7—2019.5       美国加州大学戴维斯分校                     研究科学家

　　2014.4—2019.6       美国爱荷华州立大学                            博士后 

　　2012.3—2014.3       美国德州理工大学                               博士后  

 

　　教育经历

　　2006.9 – 2011. 7        中国科学院植物研究所        博士学位            

　　2009.2 – 2010.11       德国哥廷根大学                  联合培养博士生    

　　2002.9 – 2006.7        武汉大学                             理学学士        

　　

　　研究方向

　　团队研究方向主要为运用多组学的数据探讨植物在进化过程中的演变。具体包括：1）以目前基因组学信息匮乏的蕨类和石松类植物为研究对象，利用多组学数据相结合的分析方法，探讨陆地植物进化过程中重要器官的起源和进化机制；2）以群体遗传学理论为支撑，研究作物在驯化、扩散和培育过程中有害突变的变化。

 

　　研究进展

　　1）通过全基因组重测序揭示了玉米驯化时的瓶颈效应和扩散过程中经历的一系列奠基者效应，这些居群历史动态影响了有害突变在玉米居群中的分布；

　　2）解析了玉米适应多个高海拔地区的平行进化现象；

　　3）利用全基因组重测序数据探讨了有害突变在350个来自不同育种年代的玉米品种中的变化；

　　4）通过居群转录组数据研究了杨树（Populus balsamifera）性别分化的遗传机制，并揭示了其适应高纬度气候的遗传表现。

 

 

　　PI

　　Li Wang, principle investigator. She graduated as a bachelor in biotechnology from Wuhan University in 2006 and received her Ph.D. in Plant Evolution from the Institute of Botany, Chinese Academy of Sciences in 2011. She subsequently worked as a postdoctoral researcher at Texas Tech University, Iowa State University and the University of California at Davis. As the first author or co-author, she has published a total of 8 SCI papers, including Genome Biology, New Phytologist.

　　

　　Working Experience

　　2019.7–Present      Agricultural Genomics Institute at Shenzhen-CAAS         Principle Investigator              

　　2018.7 – 2019.5     University of California, Davis, USA                                Research Scientist    

　　2014.4 – 2019.6     Iowa State University                                                         Postdoctor                              

　　2012.3 – 2014.3    Texas Tech University                                                         Postdoctor     

                        

　　Education Experience

　　2006.9–2011.7         Institute of Botany, Chinese Academy of Sciences        Ph.D        

　　2009.2–2010.11       Goettingen University, Germany                                    joint PhD student     

　　2002.9–2006.7         Wuhan University                                                           Bachelor     

 

　　Research Interests

　　Our research focuses on the genetic mechanism of plant evolution utilizing the data of multi-omics. It specifically includes: 1) to explore the origin and evolutionary mechanism of important organs in terrestrial plants with fern and lycophytes as the research subject; 2) to investigate the prevalence of deleterious mutations in the process of domestication, migration and breeding of crops employing population genetic methods.

 

　　Major Achievements

　　1) Through whole-genome resequencing, we unveiled the bottleneck effect of maize domestication and a series of founder effects during the process of range expansion. The population demography affected the prevalence of deleterious mutations in the maize population.

　　2) We revealed the genetic mechanism of parallel highland adaptation in multiple maize populations;

　　3) Using high depth whole-genome resequencing data, we explored the dynamics of deleterious mutations in 350 maize inbred lines across 60 years’ breeding history;

　　4) We disclosed the genetic mechanism of sex differentiation in Populus balsamifera with employment of population transcriptomic data, and how adaptation to high latitude environments reshaped the transcriptomes of the species.

 

　　Selected Publications

　　1. Brian Sanderson+, Li Wang+, Peter Tiffin, Zhi-qiang Wu, Matthew S. Olson*. 2019. Sex-biased expression in flowers, but not leaves. New Phytologist doi: 10.1111/nph.15421

　　2. Li Wang, Timothy Mathes Beissinger, Anne Lorant, Claudia Ross-Ibarra, Jeffrey Ross-Ibarra, Matthew Hufford. 2017. The interplay of demography and selection during maize domestication and expansion. Genome Biology 18:215.

　　3. Li Wang, Peter Tiffin, Matthew Olson. 2014. Timing for success: expression phenotype and local adaptation related to latitude in the boreal forest tree, Populus balsamifera .Tree Genetics and Genomes. DOI: 10.1007/s11295-014-0731-3.

　　4. Li Wang, Harald Schneider, Xianchun Zhang, Qiaoping Xiang. 2012. The rise of the Himalaya enforced the diversification of SE Asian ferns by altering the monsoon regimes. BMC Plant Biology 12:210. DOI: 10.1186/1471-2229-12-210.

　　5. Li Wang, Harald Schneider, Zhiqiang Wu, Lijuan He, Xianchun Zhang, Qiaoping Xiang. 2012. Indehiscent sporangia enable the accumulation of local fern diversity at the Qinghai-Tibetan Plateau. BMC Evolutionary Biology 12:158. DOI:10.1186/1471-2148-12-158.

　　6. Li Wang, Zhiqiang Wu, Nadia Bystriakova, Stephen W. Ansell, Qiaoping Xiang, Jochen Heinrichs, Harald Schneider, Xianchun Zhang. 2011. Phylogeography of the alpine fern Lepisorus clathratus on “the roof of the world”. PloS One 6: e25896. DOI: 10.1371/journal.pone.0025896.

　　7. Li Wang, Xinping Qi, Qiaoping Xiang, Jochen Heinrichs, Harald Schneider, Xianchun Zhang. 2010. Phylogeny of the paleotropical fern genus Lepisorus (Polypodiaceae, Polypodiopsida) inferred from four chloroplast genome regions. Molecular Phylogenetics and Evolution 54: 211-225.

　　8. Li Wang, Zhiqiang Wu, Qiaoping Xiang, Jochen Heinrichs, Harald Schneider, Xianchun Zhang. 2010. A molecular phylogeny and a revised classification of tribe Lepisoreae (Polypodiaceae) based on an analysis of four plastid DNA regions. Botanical Journal of the Linnean Society 162: 28-38.

 

王丽课题组更新于2020年7月