张新岩课题组

张新岩课题组

Zhang Xinyan’s Lab

　　课题组长

　　张新岩，研究员，博士生导师，农科院青年英才，深圳市“国家级领军人才”。长期从事植物分子遗传学和比较基因组学研究，研究领域涵盖植物激素、基因表达沉默及转座子生物学等，近年来以第一作者在 Science、Molecular Plant、Nucleic Acids Research等期刊发表学术论文多篇。

 

　　工作经历

　　2019.8-至今                  中国农业科学院（深圳）农业基因组研究所         研究员

　　2015.1-2019.7              普渡大学                                                            博士后

 

　　教育经历

　　2007.9-2013.6             北京大学                          博士

　　2004.9-2007.7            中国农业大学                    学士

 

　　研究内容

（一）作物功能基因组学。利用基因组学、分子遗传学和生物化学等手段解析重要农艺性状尤其是作物高产性状的遗传基础，目前以二倍体马铃薯为材料，开展块茎和匍匐茎发育的生物学机制研究。

（二）转座子-宿主相互作用。探索转座子和宿主相互作用中的军备竞赛关系，开展功能元件的鉴定和分子机制的解析，多层次揭示基因组生态的组织规律。

研究思路及进展

借助二倍体遗传学的优势推动马铃薯基础研究，挖掘关键性状调控的优良基因应用于杂交马铃薯育种。抓住功能基因组学的发展机遇和基因组重复序列的重要科学问题推动功能基因组研究。目前，课题组持续推进马铃薯产量性状的基因定位和发育生物学研究，并针对重复序列功能元件的鉴定搭建了数据分析平台，在转座子-宿主互作规律及其分子机制研究中取得了阶段性成果。

 

　　PI

　　Xinyan Zhang, Principal Investigator. Xinyan’s research is at the interface between plant functional genetics and eukaryotic genomics. His lab’s current areas of focus include the genetic dissection of agronomically important traits in crops and the ecological mechanisms in eukaryotic genome functioning.

 

　　Working Experience

　　2019.8–Present   Agricultural Genomics Institute at Shenzhen-CAAS   Principal Investigator

　　2015.1-2019.7    Purdue University                              Postdoctoral Fellow

 

　　Education Experience

　　2007.9-2013.6    Peking University                              Ph.D in plant biology                           

　　2004.9–2007.7    China Agricultural University           Bachelor 

 

　　Research Interest

　　(1) Crop functional genomics. We aim to dissect the genetic basis of agronomically important traits such as crop yield. The initial work in my lab will use diploid potato as a model system to identify genes that control yield-related traits.

　　(2) Genome ecology. We are studying the organization and function of distinct niches in orderly arranged eukaryotic genomes with particular focus on characterizing precision-targeting genetic factors at those niches.

 

　　Selected Publications

1. Zhang, X.; Zhu, Y.; Liu, X.; Hong, X.; Xu, Y.; Zhu, P.; Shen, Y.; Wu, H.; Ji, Y.; Wen, X.; Zhang, C.; Zhao, Q.; Wang, Y.; Lu, J.; Guo, H.*; Suppression of endogenous gene silencing by bidirectional cytoplasmic RNA decay in Arabidopsis, Science, 2015, 348(6230): 120-3.

2. Zhang, X.; Zhao, M.; McCarty, D.; Lisch, D.*; Transposable elements employ distinct integration strategies with respect to transcriptional landscapes in eukaryotic genomes, Nucleic Acids Res, 2020, 48(12): 6685-6698.

3. Zhang, X.; Chen, Y.; Lin, X.; Hong, X.; Zhu, Y.; Li, W.; He, W.; An, F.; Guo, H.*; Adenine phosphoribosyl transferase 1 is a key enzyme catalyzing cytokinin conversion from nucleobases to nucleotides in Arabidopsis, Mol Plant, 2013, 6(5): 1661-72.

4. Zhang, X.; Guo, H.*; mRNA decay in plants: both quantity and quality matter, Curr Opin Plant Biol, 2017, 35: 138-144.

5. Zhang, X.; Zhu, Y.; Wu, H.; Guo, H.*; Post-transcriptional gene silencing in plants: a double-edged sword, Sci China Life Sci, 2016, 59(3): 271-6.

6. Li, D.; Lu, X.; Zhu, Y.; Pan, J.; Zhou, S.; Zhang, X.; Zhu, G.; Shang, Y.; Huang, S.*; Zhang, C.*; The multi-omics basis of potato heterosis, Journal of Integrative Plant Biology, 2021.

7. Zhao, M.; Ku, J.; Liu, B.; Yang, D.; Yin, L.; Ferrell, T.; Stoll, C.; Guo, W.; Zhang, X.; Wang, D.; Wang, C.; Lisch, D.*; The mop1 mutation affects the recombination landscape in maize, Proc Natl Acad Sci U S A, 2021, 118(7): e2009475118.

8. Wu, H.#; Li, B.#; Iwakawa, H.; Pan, Y.; Tang, X.; Ling-hu, Q.; Liu, Y.; Sheng, S.; Feng, L.; Zhang, H.; Zhang, X.; Tang, Z.; Xia, X.; Zhai, J.; Guo, H.*; Plant 22-nt siRNAs mediate translational repression and stress adaptation, Nature, 2020, 581(7806): 89-93.

9. Zhu, Z.#; An, F.#; Feng, Y.; Li, P.; Xue, L.; A, M.; Jiang, Z.; Kim, J. M.; To, T. K.; Li, W.; Zhang, X.; Yu, Q.; Dong, Z.; Chen, W. Q.; Seki, M.; Zhou, J. M.; Guo, H.*; Derepression of ethylene-stabilized transcription factors (EIN3/EIL1) mediates jasmonate and ethylene signaling synergy in Arabidopsis, Proc Natl Acad Sci U S A, 2011, 108(30): 12539-44.

10. He, W.; Brumos, J.; Li, H.; Ji, Y.; Ke, M.; Gong, X.; Zeng, Q.; Li, W.; Zhang, X.; An, F.; Wen, X.; Li, P.; Chu, J.; Sun, X.; Yan, C.; Yan, N.; Xie, D. Y.; Raikhel, N.; Yang, Z.; Stepanova, A. N.; Alonso, J. M.; Guo, H.*; A small-molecule screen identifies L-kynurenine as a competitive inhibitor of TAA1/TAR activity in ethylene-directed auxin biosynthesis and root growth in Arabidopsis, Plant Cell, 2011, 23(11): 3944-60.

　

　　

　　张新岩课题组更新于2023年3月