李伟课题组

李伟课题组

Li Wei Lab

　　课题组长

　　李伟，研究员，博士生导师。2015年于中国科学院遗传与发育生物学研究所获得博士学位，2016-2019年在密西根大学进行博士后研究。主要关注植物特异性天然产物的合成途径解析和代谢工程研究，在Plant Cell，Plant Physiology等杂志发表过研究论文，2019年起担任Frontier in Plant Science代谢和化学多样性方向的审稿人。

　　工作经历

　　2020.1 - 至今中国农科院深圳农业基因组研究所研究员

　　2016.9 - 2019.12 密西根大学博士后

　　2015.2 - 2016.8 中国科学院遗传与发育生物学研究所博士后

　　教育经历

　　2009.9 - 2015.1 中国科学院遗传与发育生物学研究所博士

　　2006.9 - 2009.7 东北师范大学硕士

　　2002.9 - 2006.7 东北师范大学学士

　　研究方向

　　植物中合成丰富多样的特异性天然产物，对于植物自身的天然防御、适应性和发育具有重要意义，其中很多在人类的农业生产和健康营养中有着不可替代的应用价值。植物如何合成这些特异性天然代谢物是植物学研究中一个重要的方面，为他们的合成生物学应用提供理论基础。本课题组利用转录组、基因组和化学分析为主要手段，配合细菌、酵母、植物等多种表达体系，解析对于农艺性状和人类健康有重要应用价值的天然代谢物的合成途径，一方面利用分子遗传学手段改变农作物的代谢相关农艺性状，促进农业生产的发展；另一方面利用合成生物学理念和代谢工程手段，异源重组代谢途径，以达到大规模生产具有经济价值的天然代谢物的目的。

　　研究进展

　　利用转录组学测定和共表达分析、烟草瞬时表达和化学测定等手段，对植物天然杀虫代谢物除虫菊酯在植物中的代谢途径进行较为全面的解析。作者和其合作者先后解析了除虫菊中除虫菊酯配体：茉莉醇酮（Jasmolone）、除虫醇酮（Pyrethrolone）、第二菊酸（Pyrethric acid）等化合物相关合成酶和合成过程，并在烟草中进行了初步的合成生物学构建和检测 (Li et al, Plant Physiology, 2019; Li et al, Plant Physiology, 2018; Xu et al, New Phytologist, 2019)。

　　Wei Li, Principal Investigator, Professor, Doctoral Advisor, received his PhD degree from Institute of Genetics and Developmental Biology, Chinese Academy of Science in 2015, Worked as a Postdoc in University of Michigan from 2016 to 2019. His research focuses on elucidation of plant specialized metabolic pathway and synthetic metabolic engineering. Papers have been published on Plant Cell, Plant Physiology etc. Now he is a review editor for plant metabolism and biodiversity of Frontiers in Plant Science from 2019.

　　Working Experience

　　2020.1 – present Agricultural Genomics Institute at Shenzhen - CAAS Principal Investigator

　　2016.9 - 2019.12 University of Michigan Research fellow

　　2015.2 - 2016.8 Institute of Genetics and Developmental Biology – CAS Postdoctoral fellow

　　Education

　　2009.9 – 2015.1 Institute of Genetics and Developmental Biology - CAS PhD

　　2006.9 – 2009.7 Northeast Normal University Master

　　2002.9 – 2006.7 Northeast Normal University Bachelor

　　Research Interest

　　Plant synthesizes specialized metabolism with a vast of diversity and peculiarity. Most of them are important for defence, adaption and development of plant itself. Human are using many of those plant specialized metabolism for agricultural and health purpose. Elucidation of plant specialized metabolism and using those knowledges acquired for synthetic metabolic engineering is important for application. Our group uses transcriptome, genome, chemical analysis and multiple exogenous expression system (including bacteria, yeast and plant), to elucidate the biosynthesis pathway of plant specialized metabolism which are important for both agriculture and human health, on one hand improving crop traits related to metabolites via genetic methods, on the other hand using synthetic metabolic engineering by exogenously reassemble metabolic biosynthesis pathway to produce valuable metabolites in large scale.

　　Major Achievements

　　The biosynthesis pathway of natural pesticide pyrethrins in Tanacetum cinerariifolium was comprehensive deciphered, via methods including transcriptome and coexpression analysis, tobacco transient expression and chemical analysis etc. We and our collaborator elucidated the enzymes and reactions worked for biosynthesis of pyrethrins moieties: jasmolone, pyrethrolone and pyrethric acid, and did primary test for synthetic metabolic engineering (Li et al, Plant Physiology, 2019; Li et al, Plant Physiology, 2018; Xu et al, New Phytologist, 2019).

　　Selected Publication

　　1. Wei Li, Daniel B. Lybrand, Haiyang Xu, Fei Zhou, Robert L. Last and Eran Pichersky#, A Trichome-Specific, Plastid-Localized Tanacetum cinerariifolium Nudix Protein Hydrolyzes the Natural Pyrethrin Pesticide Biosynthetic Intermediate trans-Chrysanthemyl Diphosphate, Frontiers in Plant Science 11:482, 2020.

　　2. Wei Li, Daniel B. Lybrand, Fei Zhou, Robert L. Last, Eran Pichersky#. Pyrethrin biosynthesis: The cytochrome P450 oxidoreducatse CYP82Q3 converts jasmolone to pyrethrolone. Plant Physiology, 181: 934–944, 2019.

　　3. Haiyang Xu, Wei Li, Anthony L. Schilmiller, Henriëtte van Eekelen, Ric C. H. de Vos, Maarten A. Jongsma, Eran Pichersky#. Pyrethric acid of natural pyrethrin insecticide: complete pathway elucidation and reconstitution in Nicotiana benthamiana. New Phytologist 223: 751–765, 2019.

　　4. Ranran Wu, Fengxia Zhang, Lingyun Liu, Wei Li, Eran Pichersky, Guodong Wang#. MeNA, controlled by reversible methylation of nicotinate, is an NAD precursor that undergoes long-distance transport in Arabidopsis. Molecular Plant, 11: 1264-1277, 2018.

　　5. Wei Li, Fei Zhou, Eran Pichersky#. Jasmone hydroxylase, a key enzyme in the synthesis of the alcohol moiety of pyrethrin insecticides. Plant Physiology, 177: 1498-1509, 2018.

　　6. Wei Li*, Fengxia Zhang*, Ranran Wu*, Lijia Jia, Guosheng Li, Yalong Guo, Cuimin Liu, Guodong Wang#. A novel N-methyltransferase in Arabidopsis appears to feed a conserved pathway for nicotinate detoxification among land plants and is associated with lignin biosynthesis. Plant Physiology, 174: 1492-1504, 2017.

　　7. Wei Li, Fengxia Zhang, Yuwei Chang, Tao Zhao, ME Schranz, G Wang#, Nicotinate O-glucosylation is an evolutionarily metabolic trait important for seed germination under stress conditions in Arabidopsis thaliana. The Plant Cell, 27: 1907-1924, 2015.

　　8. Yajun Fan, Wei Li, Xiaojuan Zhu, Xingzhi Wang#. Transient expression of acidic fibroblast growth factor in pea (Pisum sativum L.) plants. African Journal of Biotechnology, 11: 6060-6063, 2012.

　　9. Yajun Fan, Wei Li, Junjie Wang, Jingying Liu, Meiying Yang, Duo Xu, Xiaojuan Zhu, Xingzhi Wang#. Efficient production of human acidic fibroblast growth factor in pea (Pisum sativum L.) plants by agroinfection of germinated seeds. BMC Biotechnology, 11: 45, 2011.

　　*Co-first author, #Corresponding author

　　Speaker

　　Plant Biology 2019 (American Society of Plant Biologists) August 3-7, 2019, San Jose.

　　李伟课题组更新于2021年2月

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